Photodynamic Laser Therapy (intravenous & interstitial)


Method

Combined application of natural and chemically derived highly specific photosensitizers and new catheter-based laser technology for light activation of these photosensitizers to induce selective destruction of tumor tissue. Additional low-dose chemotherapy with light activation of chemotherapeutic drugs.

The combination with hyperbaric oxygenation is an option to optimize therapeutic results because oxygen radicals are responsible for tumor necrosis and apoptosis. Combination with immunotherapy like macrophage activating factor GcMAF can be of benefit as well.

Natural Photosensitizers.
Other NameLaser Activator
Chlorophyll Chlorin E6 Red (660nm)
St. John’s wort Hypericin Yellow (589nm)
Curcumin Curcuminoids Blue (445nm)
Green Tea Polyphenol Epigallocatechingallate Infra Red (810nm)

Immunological Effects of Photodynamic Therapy


PDT with Low Dose Chemotherapy

In case of big tumor masses or multiple metastases the natural photosensitizers of PDT are often not effective enough. Experience has shown that tumors or metastases larger than 3-4 cm mostly cannot be destroyed by PDT alone or maybe only with multiple follow-up treatments. So if possible, tumor mass has to be reduced by surgical procedures. Secondly, chemotherapeutic drugs have a specific light absorption spectrum and their efficacy can be enhanced by stimulation with appropriate laser light (using chemotherapeutic drugs as photosensitizers). As a consequence, the drug´s dose can be reduced significantly and the well known side effects are alleviated.

Examples of this are Mitoxantron (activated by yellow and red light) which can be used successfully as a strong photosensitizer for breast cancer or malignant melanoma, and Doxorubicin (activated by blue and green light) which can be used successfully as a strong photosensitizer for many different cancers.